Wet wipes have become an essential part of many modern families’ lives, especially in inconvenient emergency situations where the convenience and single use of wet wipes has brought great convenience to consumers’ lives. The history of wet wipes as a commodity is not long, the initial wet wipes started in the 60’s from the United States, then the product was refined into different uses of wet wipes, in addition to expanding into the diaper collar city. The wet wipes market is growing rapidly in the United States and Europe, but also led to the production process and technological progress of non-woven fabrics, mainly using polyester or polyethylene, polypropylene polymer materials, but also cotton or wood pulp. The main wipes include several categories, mainly baby wipes, and personal care wipes, including general wipes, hand sanitizing wipes, facial cleaning wipes, makeup removing wipes, feminine wipes, wet toilet wipes, pet wipes, household cleaning wipes, and industrial wipes. Because of the widespread use of wipes, there has been a serious pollution of the environment, – disposable wipes fiber is difficult to degrade, and with the rapid development of toilet wipes in developed countries, the discarded wipes are easy to block the pipeline, bringing great trouble to the city sewage treatment, the urgent need for non-woven material updates and breakthroughs in technology and wood products, requiring wipes can be flushed down, can be quickly dispersed. Can be quickly dispersed. In the environment with quickly degraded.
The development of wet wipes in China began in the 1980s, with the reform and opening up of the processing from abroad, but also a small amount of the same time into the domestic market, basically as a more luxurious products. The rapid start of domestic wet wipes production was dependent on the atypical pneumonia (SARS) in 2003 for personal hygiene and the need to prevent infectious diseases, and this process was followed by the avian flu in 2004 and the swine flu in 2009, turning wet wipes as a daily necessity into a billion-yuan market. Because domestic enterprises undertake foreign processing and customization, the domestic wet wipes market is more complete, basically synchronized with foreign countries, but the normal wet wipes market growth rate is relatively slow, mainly due to the influence of education on thrift and economic purchasing power, while the relative difference between urban and rural areas in the country is relatively large.
This work of ours is to reform and optimize the liquid formula of wet wipes, with hyaluronic acid (hyaluronic acid) and Australian tea tree puree as the new formula ingredients, to launch a relatively high-end care wipes with multi-functionality. Our preliminary work in developing hyaluronic acid cosmetics and the bactericidal effect of Australian tea tree pure dew has laid a good foundation for the development of wet wipes products.
We have examined and analyzed the domestic market and production of hyaluronic acid raw materials, and believe that private enterprises have taken over and controlled the production of domestic hyaluronic acid raw materials through capital operation, and future market competition and the proliferation of hyaluronic acid fermentation production technology will lead to oversaturation of the market supply and the decline of product prices, providing a marketable space for the application of hyaluronic acid in wet wipes products. The domestic wet wipe formula is now single, basically from some formulas left behind after foreign custom processing, and companies have almost no investment in scientific research and development. We analyzed and studied the domestic market of wet wipes, found that even if the publicity has natural products or functional wet wipes are basically from the marketing point of view of the market operation, in fact, is an ordinary wet wipes.
We started to screen the formulation of the wet wipe liquid from the amount of hyaluronic acid to bring the use effect of this stagnant product closer to the cosmetic function of hydration and moisturization. Because of the difference in the fermentation process of hyaluronic acid, which may have an impact on the performance of the product, we examined the raw materials of hyaluronic acid from several different manufacturers. The hyaluronic acid samples sent by each company were made into aqueous solutions of the same concentration and then examined in terms of appearance, viscosity and skin feel, and it was found that there was almost no difference in skin feel and usage effect for hyaluronic acid for wet wipes. Considering the company’s production capacity and final pricing, we chose Dongying Foster Biotechnology Co.
The molecular weight of hyaluronic acid in the market is widely distributed, ranging from 1kDa to 3000kDa, and the moisturizing principle of different molecular weight hyaluronic acid is different. Small molecular weight hyaluronic acid, on the other hand, usually has a lower viscosity, but because of its small molecular size, it can be absorbed transdermally for deep moisturization. Therefore, the molecular weight distribution of hyaluronic acid added to the wipes is important for the skin feel and moisturizing effect of face wipes.
In order to enrich the ratios, we chose four hyaluronic acids that are widely used in the market, with molecular weights of 350 kDa, 890 kDa, 1350 kDa, and 1640 kDa, respectively. at the beginning of the experiment, we combined these four hyaluronic acids and selected 10 different formulations of hyaluronic acid components.
Hyaluronic acid forms a certain amount of anions after dissolution in water, which will precipitate with the free cations in solution. Therefore, in addition to the mildness, skin feel and cleansing effect, the most important aspect of the hyaluronic acid base formulation is the compatibility with hyaluronic acid. The main components in the base formulation of wipes are the co-humectants, surfactants and preservative systems. The formulation of hyaluronic acid wipes is also optimized in accordance with the above-mentioned elements. For the auxiliary moisturizer, we chose glycerin, which is widely used, low-priced and good at moisturizing, and hyaluronic acid to synergistically play the role of hydration, and the addition amount of glycerin was 0.01% in order to avoid that the addition of too much glycerin would affect the system’s moisture retention and skin feel measurement; for the surfactant, the mildest surfactant currently recognized in the market is the non-ionic surfactant of alkyl glucoside class (APG), which was not used in the formulation because of its high price. Considering the small amount of surfactant added in wet wipes and the fact that facial skin is usually sensitive and delicate, we chose APG0810 (carbon 8,10-alkyl glucoside) as the base glucoside surfactant with an addition of 0.1%. Although there are many different types of wipes on the market, each wipe will involve the construction of a preservative system. In the development of wet wipes for more than half a century, the antiseptic system is already very mature, so we integrated the more widely used antiseptic system in the market, the final determination of the antiseptic system of bacteriostatic agents include bromoxynil propylene glycol (7.5 ppm), phenoxyethanol 0.1%, methylisocerazolinone (11.25 ppm), methylchloroisocerazolinone (3.75 ppm) and citric acid 0.06% .
Based on our preliminary work, ten formulations of hyaluronic acid face wipes were selected. In order to screen for the best hyaluronic acid molecular weight distribution, the total addition of hyaluronic acid in each of our formulations was 0.04%. In terms of formulation evaluation, our test was divided into five aspects of skin sensory experience in the preliminary analysis and a quantitative study of moisturizing and hydrating effects in the later stage.
In the preliminary skin feel test, we found 30 volunteers of different genders and ages to test the skin feel through five aspects of moisture retention, smoothness, absorption time, stickiness and irritation. The volunteers scored and judged the above aspects after using the wipes, including moisture retention and smoothness, using a 10-point scale, with 0 points representing a bad experience and 10 points representing a very satisfactory one.
Through the moisture retention evaluation, we selected the three best formulations, namely formulation 4, formulation 9 and formulation 10, whose hyaluronic acid distribution was 890kDa/1350kDa(1:1),890kDa/1350kDa/1640kDa (1:1:1) and 350kDa/890kDa/1350kDa/1640kDa (1:1:1), respectively. :1:1:1). By the smoothness evaluation, we screened out the three best formulations, which were formulation 5, formulation 6 and formulation 10. The hyaluronic acid distribution of formulations 5 and 6 were 890kDa/1640kDa (1:1) and 1350kDa/1640kDa (1:1), respectively. In terms of volunteer feedback, the absorption times of the ten hyaluronic acid wipes were similar. All of them can bring good skin feeling experience to the testers. The absorption time ranged from 4.23 seconds (formulation 1, hyaluronic acid 350 kDa/890 kDa (1:1) to 5.88 seconds (formulation 6, hyaluronic acid 1350 kDa/1640 kDa 1:1). none of the 30 test subjects felt irritation in the wipes, and three people had a slight This sensation ended after the wipes were absorbed (mean absorption time 5.88s).
The four hyaluronic acid face wipe formulations with the best overall scores in terms of moisture retention and smoothness were selected as formulations 4, 6, 9, and 10. Subsequently, a quantitative analysis of moisture retention was performed on these four formulations. There are many methods for measuring the moisture retention of products, and the methods that are currently well accepted both at home and abroad include the skin water content (MMV) test and the skin water loss measurement method (TEWL method). The measurement of skin water content alone does not reflect the role of the product skin barrier. Therefore, in this experiment, the water content method and the skin water loss measurement method (TEWL method) were combined to more comprehensively evaluate the moisturizing efficacy of hyaluronic acid wipes with different molecular weights.
For testing the moisturizing ability of hyaluronic acid wipes, 53 volunteers of different genders and ages were identified, and we recorded skin hydration and water loss values at 0.5 h, 1 h, 2 h, 4 h, 6 h, and 8 h after wipe application and conducted data study and analysis. The results of the study showed that all four hyaluronic acid wipes were effective in hydrating all types of skin. In particular, formulation 9 maintained a good hydration effect after 4 hours of use, while formulation 6 had a better hydration effect than formulation 9 for dry skin after 4 hours. in terms of skin moisture loss values, the advantage of formulation 9 was more obvious, indicating that large molecules of hyaluronic acid (1350 kDa and 1640 kDa) have an increased moisturizing effect on skin barrier function and transported to dry skin. Restorative moisturization.
Combining skin experience and skin moisturization, formulation 9 is suitable as a formulation for mass-produced hyaluronic acid face wipes, while at the same time, for dry damaged skin, formulation 6 has some advantages for its more excellent hydration performance. Since there is a certain amount of time between the production and use of the wipes, we conducted moisturizing stability tests on the screened hyaluronic acid wipes Formulation 6 and Formulation 9.
In order to check the stability of the moisturizing effect of hyaluronic acid wipes, four packs of hyaluronic acid wipes were made according to formulations 6 and 9, respectively. These wipes were placed in four different temperature environments for 72 hours at 0°C, 25°C, and 45°C temperatures, and were examined at constant temperatures. Also examined at 0°C and 45°C temperature changes. Then placed at 25°C for 60 days. We found no abnormalities in the appearance of any of the wipes at the end of the experiment and evaluated the moisturizing effect of the wipes treated under four different extreme temperature conditions. We found 10 volunteers for hydration testing and the results of the experiment showed that the moisturizing effect of hyaluronic acid wipes treated at the extremes was not affected.
The addition of Australian tea tree puree to the liquid formulation of the wipes is a new experiment, which highlights the application of germicidal agents as an ingredient of traditional natural product origin. Our partner company is an Australian multinational tea tree grower and tea tree essential oil producer, controlling 60% of the world’s tea tree essential oil production, and there was a need to find value in the hydro-distillation process that could be exploited and utilized. The development and use of tea tree pure essential oil continues the traditional application of Australian tea tree essential oil, making full use of the secondary exploitation of natural resources and the water solubility of tea tree pure essential oil.
We used the antibacterial activity of tea tree pure dew to make several types of wipes with different amounts of tea tree pure dew for antibacterial experiments. To make the base wipes formulation of tea tree pure dew, we added glycerol 0.01%, benzalkonium chloride 0.1%, bromoxynil 7.5 ppm, phenoxyethanol 0.1%, methylisocerazolinone 11.25 ppm, methylchloroisocerazolinone 3.75 ppm, and citric acid 0.06%. Six different tea tree pure wipes were made with 0%, 20%, 40%, 60%, 80% and 100% tea tree pure wipes.
We used the paper diffusion method to determine the antibacterial activity of the six wipes against E. coli, Staphylococcus aureus and Candida albicans. 20% tea tree pure dew wipes were not effective against E. coli with the highest antibacterial rate of 68.78%, while 40% tea tree pure dew wipes were not effective against Candida albicans with the highest antibacterial rate of 57.23%. 60% tea tree pure dew wipes were not effective against E. coli and Staphylococcus aureus were over 90% (91.24% and 97.12%) after two minutes of contact, but the effect of Candida albicans was relatively weak, with 73.14% after 20 minutes. We found that 80% tea tree pure dew wipes were more effective than 100% tea tree pure dew wipes in inhibiting Escherichia coli, Staphylococcus aureus and Candida albicans.
We modified the 80% Tea Tree Pure Dew wipes by using larger wipes with non-woven fabric (20cmx30cm) and increasing the amount of wipe liquid (wipe liquid/wipes, 6.5:1) to apply it to foot cleaning and sterilization. We also improved and optimized the formulation of 60% tea tree pure wipes by adding some moisturizing and lubricating ingredients, including aloe vera extract and propylene glycol. Applied to the special wipes for hemorrhoid care, to make a special wipes with both cleaning and sterilization, to replace the ordinary wet toilet paper. These two wipes are currently being developed in cooperation with wet wipe manufacturers and are now ready for production.
—–wirted by wet wipes machine manufacturer